Intracellular reduction/activation of a disulfide switch in thiosemicarbazone iron chelators
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چکیده
منابع مشابه
Intracellular reduction/activation of a disulfide switch in thiosemicarbazone iron chelators.
Iron scavengers (chelators) offer therapeutic opportunities in anticancer drug design by targeting the increased demand for iron in cancer cells as compared to normal cells. Prochelation approaches are expected to avoid systemic iron depletion as chelators are liberated under specific intracellular conditions. In the strategy described herein, a disulfide linkage is employed as a redox-directed...
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The primary targets of iron chelators used for treating transfusional iron overload are prevention of iron ingress into tissues and its intracellular scavenging. The present study was aimed at elucidating the capacity of clinically important iron chelators such as deferiprone (DFP), desferrioxamine, and ICL670 to (a) gain direct access to intracellular iron pools of key cells of iron accumulati...
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ژورنال
عنوان ژورنال: Metallomics
سال: 2014
ISSN: 1756-5901,1756-591X
DOI: 10.1039/c4mt00153b